About En

2012-08-22T04:27:56Z

Modern medical diagnostics is impossible without physical-chemical analysis. Most of biologically significant substances possess electrochemical activity and can be well-detected by means of electro-analytical methods. De facto, a particular method has become a standard one among the researchers of other countries: a sample is split in a chromatographer, its components are identified by the time they hold within a column and by their electrochemical behavior, while their quantity is identified on the basis of peak signal amplitude and space (e.g. US patent #6,558,955 dated 06.05.2003 Methodology for Predicting and/or Diagnosing Disease). Such analysis can be performed, for instance, by a system of high-performance liquid chromatography (HPLC) with a multichannel coulometric detector made by DIONEX/ESA Products (www.esainc.com), Namely CoulArray® Multi-Channel ECD system, which sometimes in terms of sensitivity and selectivity is better than HEFC systems with mass-spectrometer detector used by Metabolon Company (www.metabolon.com). The list of diseases that can be detected by means of patented methods is far longer, than the list of diseases that must be identified by a mobile diagnostic device (e.g., US patent #7,947,453 dated 24.05.2011 Methods for Drug Discovery, Disease Treatment, and Diagnosis Using Metabolomics). Modern methods for recognition of images combined with high selectivity of the system provide for diagnostics per general concept of metabolites (i.e. metabolic profile) in a sample rather than per separate biomarkers. However, high cost of the equipment is still the main obstacle preventing integration of these methods in general medical practice. The proposed concept of Mobile Diagnostic Device is based on comparison of a metabolic profile of the sample (i.e. its electrochemical image – composite 3D electrochemical signal) with signals from the database. Electrochemical image of the sample is obtained by means of upgraded method of electrochemical analysis of fluid (RF patent №2382354 dated 20.02.2010) using some know-hows of the applicants. At that, composite 3D electrochemical signal is obtained by means of portable tester which transmits it for further processing at a remote centre; and technically challenging stage of chromatographic separation of a sample is replaced by electro kinetic separation. We assume that this concept suits the detection of monoclonal protein (M-protein or Bence Jones protein) by means of electrophoresis of protein fractions in patient’s urine to reveal myeloma. At that, selectivity of our electrochemical detector combines two stages – analysis of protein fractions and identification of M-protein in one measurement.

2012-08-22T04:27:56Z

One of the team members has particular background related to development of medical equipment. Since 1996 he has been engaged in development of electrochemical analysis methods for water solutions applied in ecology. In 2000 a prototype of portable water analyzer was developed and tested (lead, cadmium and copper ions). Pilot lot of disposable electrochemical sensors was produced. Two prototypes of highly-selective electrochemical HPLC detectors were designed and produced.

2012-08-22T04:27:56Z

Project team – a group of former and current employees of RFNC-VNIITF that joined their efforts while implementing the ISTC Project №342 and developing a field portable electrochemical equipment to detect heavy metals in the water (http://www.istc.ru/istc/archive/docsc1.nsf/ludi/w0003145/$FILE/w0003145.pdf). Some of them participated in R&D activities «Electrochemical Detector for High-performance liquid chromatography» under the seed-funding program START-2004 (Project №5104).

2012-08-22T04:27:56Z

We have partners in the field of electrochemistry – members Brainina H.Z., Doctor of Chemistry (Yekaterinburg). We seek partnership with medics, diagnosticians, biologists and chemists-analysts.

2012-08-22T04:27:56Z

We are ready to discuss any options – participation in stock capital, foundation of a new company and etc.

2012-08-22T04:27:56Z

The method of electrochemical analysis of fluids was patented twice. Universal software-hardware complex for mastering of various modes of sensor operation was created. Several solutions were considered to complete two designs of sensor with different separation mechanisms. Estimations of general parameters of the sensors were done. The components for sensor prototyping were made. One of the designs of electro-kinetic separators was prototyped. Patent search was done.

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2012-08-02T04:43:15Z

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